Likelihood Calculation Conditional on Observed Pedigree Structure
نویسندگان
چکیده
منابع مشابه
Efficient maximum likelihood pedigree reconstruction.
A simple and efficient algorithm is presented for finding a maximum likelihood pedigree using microsatellite (STR) genotype information on a complete sample of related individuals. The computational complexity of the algorithm is at worst (O(n(3)2(n))), where n is the number of individuals. Thus it is possible to exhaustively search the space of all pedigrees of up to thirty individuals for one...
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In .an~ysesofthefamilialidistributiOn.9~/~~neti£)t:rflits,alikelihoodappr~a(;h is usually taken-.It is o~~nnecessarythatsu(;h likelihood$beconclition~ upon aspects 9fthepopulation stl'u.(;ture and Sampling procedure. ·lnthefieldof>llleclicalgeneticanalyses,efficiency and information areiimpormntcritena, to bebalancedi ~gflinst the requirements of robustness and simplicity of application. In man...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 1998
ISSN: 0002-9297
DOI: 10.1086/301770